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Results of the interim analysis of a prospective, multicenter, observational study of small subepithelial lesions in the stomach.

Authors :
Iwamuro M
Mitsuhashi T
Inaba T
Matsueda K
Nagahara T
Takeuchi Y
Doyama H
Mizuno M
Yada T
Kawai Y
Nakamura J
Matsubara M
Nebiki H
Niimi K
Toyokawa T
Takenaka R
Takeda S
Tanaka S
Nishimura M
Tsuzuki T
Akahoshi K
Furuta T
Haruma K
Okada H
Source :
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society [Dig Endosc] 2024 Mar; Vol. 36 (3), pp. 323-331. Date of Electronic Publication: 2023 Jun 15.
Publication Year :
2024

Abstract

Objectives: Long-term outcomes of gastric subepithelial lesions have not been elucidated. To reveal the natural history, we initiated a prospective, 10-year follow-up of patients with small (≤20 mm) gastric subepithelial lesions in September 2014. Here, we report the results of an interim analysis of a prospective observational study.<br />Methods: In total, 567 patients with 610 lesions were prospectively registered between September 2014 and August 2016. The location, size, morphology, and number of subepithelial lesions were recorded on a web-based case report form. This study has been conducted as an Academic Committee Working Group of the Japan Gastroenterological Endoscopy Society.<br />Results: The endoscopic follow-up period was 4.60 ± 1.73 years (mean ± standard deviation), and survival data were investigated for 5.28 ± 1.68 years. This interim analysis revealed that the estimated cumulative incidence of a size increase ≥5 mm, after accounting for patients' death and resection of the tumor as competing risk events, was 4.5% at 5 years. In addition, the estimated cumulative incidence of lesion size increase ≥5 mm or resection of lesions was 7.9% at 5 years, and that of size increase ≥10 mm or resection of lesions was 4.5% at 5 years.<br />Conclusion: These results indicate that approximately one in 13 patients with small (≤20 mm) gastric subepithelial lesions may require resection or further investigation for increased tumor size (≥5 mm) within 5 years.<br /> (© 2023 Japan Gastroenterological Endoscopy Society.)

Details

Language :
English
ISSN :
1443-1661
Volume :
36
Issue :
3
Database :
MEDLINE
Journal :
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Publication Type :
Academic Journal
Accession number :
37183338
Full Text :
https://doi.org/10.1111/den.14595