Muscle fusogens go viral for gene delivery to skeletal muscle.

Viruses and multinucleated cells rely on fusogens to facilitate the fusion of their membranes. In this issue of Cell, Millay and colleagues demonstrate that replacing viral fusogens with mammalian skeletal muscle fusogens leads to the specific transduction of skeletal muscle and the ability to deliver gene therapy constructs in a therapeutically relevant muscle disease.
Competing Interests: Declaration of interests A.D.P. is a co-founder and scientific advisor to MyoGene Bio, San Diego, CA, USA.
(Published by Elsevier Inc.)