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Cohort profile update: Tehran cardiometabolic genetic study.

Authors :: Daneshpour MS
Akbarzadeh M
Lanjanian H
Sedaghati-Khayat B
Guity K
Masjoudi S
Zahedi AS
Moazzam-Jazi M
Bonab LNH
Shalbafan B
Asgarian S
Farhood GK
Javanrooh N
Zarkesh M
Riahi P
Moghaddas MR
Dehkordi PA
Ahmadi AD
Hosseini F
Farahani SJ
Hadaegh F
Mirmiran P
Tehrani FR
Ghanbarian A
Pasand MSFM
Amiri P
Valizadeh M
Hosseipanah F
Tohidi M
Ghasemi A
Zadeh-Vakili A
Piryaei M
Alamdari S
Khalili D
Momenan A
Barzin M
Zeinali S
Hedayati M
Azizi F
Source :: European journal of epidemiology [Eur J Epidemiol] 2023 Jun; Vol. 38 (6), pp. 699-711. Date of Electronic Publication: 2023 May 12.
Publication Year :: 2023
Abstract: The Tehran cardiometabolic genetic study (TCGS) is a large population-based cohort study that conducts periodic follow-ups. TCGS has created a comprehensive database comprising 20,367 participants born between 1911 and 2015 selected from four main ongoing studies in a family-based longitudinal framework. The study's primary goal is to identify the potential targets for prevention and intervention for non-communicable diseases that may develop in mid-life and late life. TCGS cohort focuses on cardiovascular, endocrine, metabolic abnormalities, cancers, and some inherited diseases. Since 2017, the TCGS cohort has augmented by encoding all health-related complications, including hospitalization outcomes and self-reports according to ICD11 coding, and verifying consanguineous marriage using genetic markers. This research provides an update on the rationale and design of the study, summarizes its findings, and outlines the objectives for precision medicine.<br /> (© 2023. Springer Nature B.V.)