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Postmortem diagnosis of Takotsubo syndrome on autoptic findings: is it reliable? A systematic review.

Authors :
Grassi S
Campuzano O
Cazzato F
Coll M
Puggioni A
Zedda M
Arena V
Iglesias A
Sarquella-Brugada G
Pinchi V
Brugada R
Oliva A
Source :
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology [Cardiovasc Pathol] 2023 Jul-Aug; Vol. 65, pp. 107543. Date of Electronic Publication: 2023 May 09.
Publication Year :
2023

Abstract

Takotsubo syndrome (TTS) is a cardiac syndrome characterized by transient left ventricular systolic dysfunction in the absence of significant obstructive coronary artery disease. At the autopsy, its diagnosis is often challenging, since it is generally thought that it relates to no characteristic macroscopic or microscopic findings. In order to verify this last statement, we performed a systematic review of the literature following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA) criteria. To the best of our knowledge, it is the first systematic review addressing this issue. We identified recurring but not pathognomonic (microscopic) features of TTS: contraction band necrosis and non-specific inflammatory changes (e.g., interstitial infiltrates of mononuclear lymphocytes and macrophages) typically in the absence of microscopic findings typical of acute myocardial infarction. In cases of TTS-related sudden death, careful evaluation of anamnesis, autopsy data and post-mortem genetic results (to exclude other causes) should be considered to overcome the complexity of these cases.<br />Competing Interests: Declaration of Competing Interest All authors declare that they have no conflict of interest.<br /> (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1879-1336
Volume :
65
Database :
MEDLINE
Journal :
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
Publication Type :
Academic Journal
Accession number :
37169210
Full Text :
https://doi.org/10.1016/j.carpath.2023.107543