Back to Search
Start Over
Acarbose Mitigates Age-Dependent Alterations in Erythrocyte Membrane Transporters During Aging in Rats.
- Source :
-
Rejuvenation research [Rejuvenation Res] 2023 Aug; Vol. 26 (4), pp. 139-146. Date of Electronic Publication: 2023 Jun 12. - Publication Year :
- 2023
-
Abstract
- Acarbose (ACA), a well-studied and effective inhibitor of α-amylase and α-glucosidase, is a postprandial-acting antidiabetic medicine. The membrane of the erythrocyte is an excellent tool for analyzing different physiological and biochemical activities since it experiences a range of metabolic alterations throughout aging. It is uncertain if ACA modulates erythrocyte membrane activities in an age-dependent manner. As a result, the current study was conducted to explore the influence of ACA on age-dependent deteriorated functions of transporters/exchangers, disrupted levels of various biomarkers such as lipid hydroperoxides (LHs), protein carbonyl (PCO), sialic acid (SA), total thiol (-SH), and erythrocyte membrane osmotic fragility. In addition to a concurrent increase in Na <superscript>+</superscript> /H <superscript>+</superscript> exchanger activity and concentration of LH, PCO, and osmotic fragility, we also detected a considerable decrease in membrane-linked activities of Ca <superscript>2+</superscript> -ATPase (PMCA) and Na <superscript>+</superscript> /K <superscript>+</superscript> -ATPase (NKA), as well as concentrations of SA and -SH in old-aged rats. The aging-induced impairment of the activities of membrane-bound ATPases and the changed levels of redox biomarkers were shown to be effectively restored by ACA treatment.
- Subjects :
- Lipid Peroxides analysis
Sialic Acids analysis
Protein Carbonylation drug effects
Sulfhydryl Compounds analysis
Osmotic Fragility drug effects
Animals
Rats
Male
Rats, Wistar
Oxidation-Reduction drug effects
Biomarkers analysis
Biomarkers metabolism
Acarbose pharmacology
Glycoside Hydrolase Inhibitors pharmacology
Erythrocyte Membrane chemistry
Erythrocyte Membrane drug effects
Erythrocyte Membrane enzymology
Aging drug effects
Aging metabolism
Plasma Membrane Calcium-Transporting ATPases analysis
Plasma Membrane Calcium-Transporting ATPases metabolism
Sodium-Potassium-Exchanging ATPase analysis
Sodium-Potassium-Exchanging ATPase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8577
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Rejuvenation research
- Publication Type :
- Academic Journal
- Accession number :
- 37166369
- Full Text :
- https://doi.org/10.1089/rej.2023.0010