Antimalarial ceramicines Q-T from Chisocheton ceramicus.

Authors :: Nugroho AE
Wong CP
Hirasawa Y
Kaneda T
Tougan T
Horii T
Hadi AHA
Morita H
Source :: Journal of natural medicines [J Nat Med] 2023 Jun; Vol. 77 (3), pp. 596-603. Date of Electronic Publication: 2023 May 10.
Publication Year :: 2023
Abstract: Ceramicines are a series of limonoids that were isolated from the bark of Malaysian Chisocheton ceramicus (Meliaceae) and were known to show various biological activity. Four new limonoids, ceramicines Q-T (1-4) were isolated from the barks of C. ceramicus, and their structures were determined on the basis of the 1D and 2D NMR analyses in combination with calculated <superscript>13</superscript> C chemical shift data. Ceramicines Q-T (1-4) were established to be new limonoids with a cyclopentanone[α]phenanthren ring system with a β-furyl ring at C-17, and without a tetrahydrofuran ring like ceramicine B, which is characteristic of known ceramicines. Ceramicine R (2) exhibited potent antimalarial activity against Plasmodium falciparum 3D7 strain with IC <subscript>50</subscript> value of 2.8 µM.<br /> (© 2023. The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy.)