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Home-based self-sampling vs clinician sampling for anal precancer screening: The Prevent Anal Cancer Self-Swab Study.
- Source :
-
International journal of cancer [Int J Cancer] 2023 Aug 15; Vol. 153 (4), pp. 843-853. Date of Electronic Publication: 2023 May 09. - Publication Year :
- 2023
-
Abstract
- Sexual minority men are at increased risk for anal squamous cell carcinoma. Our objective was to compare screening engagement among individuals randomized to self-collect an anal canal specimen at home or to attend a clinic appointment. Specimen adequacy was then assessed for human papillomavirus (HPV) DNA genotyping. A randomized trial recruited cisgendered sexual minority men and transgender people in the community and assigned them to use a home-based self-collection swabbing kit or attend a clinic-based swabbing. Swabs were sent for HPV genotyping. The proportions of participants completing screening in each study arm and the adequacy of their specimens for HPV genotyping were assessed. Relative risks were estimated for factors associated with screening. A total of 240 individuals were randomized. Age (median, 46 years) and HIV status (27.1% living with HIV) did not differ by study arm. A total of 89.2% and 74.2% of home-arm and clinic-arm individuals returned the swab, respectively (P = .003), difference between groups, 15.0% (95% CI 5.4%-24.6%). Among black individuals, 96.2% and 63.2% in the home and clinic arms screened (P = .006). Among individuals with HIV, 89.5% and 51.9% in the home and clinic arms screened (P < .001). Self-collected swabs and clinician-collected swabs were comparable in adequacy for HPV genotyping (96.3% and 93.3%, respectively). People at highest risk for anal cancer may be more likely to screen if they are able to self-collect swabs at home rather than attend a clinic.<br /> (© 2023 UICC.)
- Subjects :
- Male
Humans
Middle Aged
Anal Canal pathology
Papillomaviridae genetics
Early Detection of Cancer
Homosexuality, Male
Papillomavirus Infections complications
Papillomavirus Infections diagnosis
Anus Neoplasms diagnosis
Anus Neoplasms prevention & control
Anus Neoplasms pathology
HIV Infections complications
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0215
- Volume :
- 153
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 37158105
- Full Text :
- https://doi.org/10.1002/ijc.34553