What Causes Seizures in Neurocysticercosis?

Authors :: Steyn TJS
Awala AN
de Lange A
Raimondo JV
Source :: Epilepsy currents [Epilepsy Curr] 2022 Dec 21; Vol. 23 (2), pp. 105-112. Date of Electronic Publication: 2022 Dec 21 (Print Publication: 2023).
Publication Year :: 2022
Abstract: Neurocysticercosis (NCC) is the most prevalent parasitic infection of the central nervous system. It is caused by the presence of larvae of the cestode Taenia solium in the brain. The most common symptom of NCC is seizures, and it is widely considered the world's leading cause of preventable epilepsy. Despite the prevalence and impact of NCC, a thorough, mechanistic understanding of seizure generation is still lacking. In this review, we address the question "What causes seizures in NCC?" by summarizing and discussing the major theories that seek to explain the seizurogenic and epileptogenic processes in this disorder. In addition, we highlight the potential for recent advances in disease modeling to help accelerate progress in this area.<br />Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.<br /> (© The Author(s) 2022.)