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Impact of body mass index on size and composition of urinary stones: a systematic review and meta-analysis.
- Source :
-
International braz j urol : official journal of the Brazilian Society of Urology [Int Braz J Urol] 2023 May-Jun; Vol. 49 (3), pp. 281-298. - Publication Year :
- 2023
-
Abstract
- Background: Several studies have explored the impact of BMI on size and composition of urinary stones. Because there were controversies, a meta-analysis was necessary to be carried out to provide some evidence of the relationship of BMI and urolithiasis.<br />Materials and Methods: PubMed, Medline, Embase, Web of Science databases, and the Cochrane Library were searched up to August 12th 2022 for eligible studies. The urolithiasis patients were summarized into two groups: BMI < 25 and ≥ 25 kg/m2. Summary weighted mean difference (WMD), relative risk (RR) and 95% confidence intervals (CI) were calculated through random effects models in RevMan 5.4 software.<br />Results: A total of fifteen studies involving 13,233 patients were enrolled in this meta-analysis. There was no significant correlation of BMI and size of urinary stone (WMD -0.13mm, 95% CI [-0.98, 0.73], p = 0.77). Overweight and obesity increased the risk of uric acid stones in both genders and in different regions (RR=0.87, [95% CI] = 0.83, 0.91, p<0.00001). There was a higher risk of calcium oxalate stones formation in overweight and obesity group in total patients (RR=0.95, [95% CI] = 0.91, 0.98, p = 0.006). The relationship of BMI and calcium phosphate was not observed in this meta-analysis (RR=1.12, [95% CI] = 0.98, 1.26, p = 0.09). Sensitivity analysis was performed and indicated similar results.<br />Conclusions: The current evidence suggests a positive association between BMI and uric acid and calcium oxalate stones. It would be of great guiding significance to consider losing weight when treating and preventing urinary stones.<br />Competing Interests: None declared.<br /> (Copyright® by the International Brazilian Journal of Urology.)
Details
- Language :
- English
- ISSN :
- 1677-6119
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International braz j urol : official journal of the Brazilian Society of Urology
- Publication Type :
- Academic Journal
- Accession number :
- 37115175
- Full Text :
- https://doi.org/10.1590/S1677-5538.IBJU.2022.0587