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Quality of Life in Teduglutide-Treated Patients with Short Bowel Syndrome Intestinal Failure-A Nested Matched Pair Real-World Study.
- Source :
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Nutrients [Nutrients] 2023 Apr 18; Vol. 15 (8). Date of Electronic Publication: 2023 Apr 18. - Publication Year :
- 2023
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Abstract
- Background: Quality of life (QoL) data of chronic intestinal failure (cIF) patients treated with the GLP-2 analogue teduglutide are scarce. This study aims to analyze QoL changes over time in teduglutide-treated patients and compare the results to a matched non-treated cIF control group in a real-world setting.<br />Methods: QoL data (SF-36 and SBS-QoL <superscript>TM</superscript> ) were obtained from adult cIF patients being treated with teduglutide and compared to previously collected QoL data from a PNLiver trial (DRKS00010993), during which patients had been therapy naive. The dataset was then extended by a pairwise matched control group (non-teduglutide-treated PNLiver trial patients) and follow-up data from this group were collected accordingly.<br />Results: Median teduglutide treatment duration and the follow-up period of controls were both 4.3 years. SBS-QoL <superscript>TM</superscript> subscales and the SBS-QoL <superscript>TM</superscript> sum score showed significant improvements over time in teduglutide-treated patients, as well as for the SF-36 physical and mental component summary scores (all p < 0.02), while non-treated patients showed no significant changes in any of the mentioned scores. Significant differences of QoL changes between treated and non-treated patients were seen for both SF-36 summary scores ( p = 0.031 and 0.012).<br />Conclusions: We herein demonstrate for the first time that QoL significantly improved during teduglutide treatment in SBS-cIF patients in a real-world setting compared to individually matched non-treated SBS-cIF patients, indicating relevant clinical benefits.
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 37111167
- Full Text :
- https://doi.org/10.3390/nu15081949