Immunomodulating activities associated with the cytosol fraction of a 3-methylcholanthrene-induced rat fibrosarcoma--II. Association with polyamine complexes.

Authors :: Pommier GJ
Garrouste F
Remacle-Bonnet MM
Depieds RC
Source :: The International journal of biochemistry [Int J Biochem] 1986; Vol. 18 (6), pp. 557-64.
Publication Year :: 1986
Abstract: This paper characterizes the molecular nature of the factors present in cytosol from F-344 rat McFiFi2(s) fibrosarcoma cells (FiCF) which mediate inhibition of PHA-induced lymphoproliferative responses. These are polyamines (spermine/spermidine) conjugated to different protein carriers. Interaction of these complexes with polyamine oxidase (PAO) present in fetal calf or rat serum is responsible of the suppression observed.

Subjects :: Animals
Cattle
Cytosol immunology
Fibrosarcoma chemically induced
Fibrosarcoma metabolism
Guanidines pharmacology
Kinetics
Lymphocyte Activation
Methylcholanthrene
Oxidoreductases Acting on CH-NH Group Donors antagonists & inhibitors
Rats
Polyamine Oxidase
Fibrosarcoma immunology
Immune Tolerance
Neoplasm Proteins immunology
Oxidoreductases Acting on CH-NH Group Donors immunology
Polyamines immunology

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