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CD30 co-stimulation drives differentiation of protective T cells during Mycobacterium tuberculosis infection.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2023 Aug 07; Vol. 220 (8). Date of Electronic Publication: 2023 Apr 25. - Publication Year :
- 2023
-
Abstract
- Control of Mycobacterium tuberculosis (Mtb) infection requires generation of T cells that migrate to granulomas, complex immune structures surrounding sites of bacterial replication. Here we compared the gene expression profiles of T cells in pulmonary granulomas, bronchoalveolar lavage, and blood of Mtb-infected rhesus macaques to identify granuloma-enriched T cell genes. TNFRSF8/CD30 was among the top genes upregulated in both CD4 and CD8 T cells from granulomas. In mice, CD30 expression on CD4 T cells is required for survival of Mtb infection, and there is no major role for CD30 in protection by other cell types. Transcriptomic comparison of WT and CD30-/- CD4 T cells from the lungs of Mtb-infected mixed bone marrow chimeric mice showed that CD30 directly promotes CD4 T cell differentiation and the expression of multiple effector molecules. These results demonstrate that the CD30 co-stimulatory axis is highly upregulated on granuloma T cells and is critical for protective T cell responses against Mtb infection.<br /> (This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.)
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 220
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 37097292
- Full Text :
- https://doi.org/10.1084/jem.20222090