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Altered gyrification in chemotherapy-treated older long-term breast cancer survivors.
- Source :
-
Research square [Res Sq] 2023 Apr 10. Date of Electronic Publication: 2023 Apr 10. - Publication Year :
- 2023
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Abstract
- Purpose: The purpose of this prospective longitudinal study was to evaluate the changes in brain surface gyrification in older long-term breast cancer survivors 5 to 15 years after chemotherapy treatment.<br />Methods: Older breast cancer survivors aged ≥ 65 years treated with chemotherapy (C+) or without chemotherapy (C-) 5-15 years prior and age & sex-matched healthy controls (HC) were recruited (time point 1 (TP1)) and followed up for 2 years (time point 2 (TP2)). Study assessments for both time points included neuropsychological (NP) testing with the NIH Toolbox cognition battery and cortical gyrification analysis based on brain MRI.<br />Results: The study cohort with data for both TP1 and TP2 consisted of the following: 10 participants for the C+ group, 12 participants for the C- group, and 13 participants for the HC group. The C+ group had increased gyrification in 6 local gyrus regions including the right fusiform, paracentral, precuneus, superior, middle temporal gyri and left pars opercularis gyrus, and it had decreased gyrification in 2 local gyrus regions from TP1 to TP2 ( p < 0.05, Bonferroni corrected). The C- and HC groups showed decreased gyrification only ( p < 0.05, Bonferroni corrected). In C+ group, changes in right paracentral gyrification and crystalized composite scores were negatively correlated ( R = -0.76, p = 0.01).<br />Conclusions: Altered gyrification could be the neural correlate of cognitive changes in older chemotherapy-treated long-term breast cancer survivors.
Details
- Language :
- English
- ISSN :
- 2693-5015
- Database :
- MEDLINE
- Journal :
- Research square
- Accession number :
- 37090667
- Full Text :
- https://doi.org/10.21203/rs.3.rs-2697378/v1