Back to Search
Start Over
Immediate hypersensitivity reactions to antineoplastic agents - A practical guide for the oncologist.
- Source :
-
Cancer treatment reviews [Cancer Treat Rev] 2023 May; Vol. 116, pp. 102559. Date of Electronic Publication: 2023 Apr 13. - Publication Year :
- 2023
-
Abstract
- Immediate hypersensitivity reactions (IHRs) to antineoplastic agents occur frequently, and every oncologist will encounter these reactions in their clinical practice at some point. The clinical signature of IHRs can range from mild to life-threatening, and their occurrence can substantially impede the treatment course of patients with cancer. Yet, clear guidelines regarding the diagnosis and management are scarce, especially from an oncologic point of view. Therefore, herein, we review the definition, pathophysiology, epidemiology, diagnosis and management of IHRs to chemotherapeutic agents and monoclonal antibodies. First, we focus on defining the specific entities that comprise IHRs and discuss their underlying mechanisms. Then, we summarize the epidemiology for the antineoplastic agents that represent the most common causes of IHRs, i.e., platinum compounds, taxanes and monoclonal antibodies (mAbs). Next, we describe the possible clinical pictures and the comprehensive diagnostic work-up that should be executed to identify the culprit and safe alternatives for the future. Finally, we finish with reviewing the treatment options in both the acute phase and after recovery, with the aim to improve the oncologic care of patients with cancer.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Antibodies, Monoclonal therapeutic use
Drug Hypersensitivity diagnosis
Drug Hypersensitivity epidemiology
Drug Hypersensitivity etiology
Antineoplastic Agents therapeutic use
Hypersensitivity, Immediate chemically induced
Hypersensitivity, Immediate complications
Hypersensitivity, Immediate drug therapy
Neoplasms complications
Oncologists
Subjects
Details
- Language :
- English
- ISSN :
- 1532-1967
- Volume :
- 116
- Database :
- MEDLINE
- Journal :
- Cancer treatment reviews
- Publication Type :
- Academic Journal
- Accession number :
- 37084565
- Full Text :
- https://doi.org/10.1016/j.ctrv.2023.102559