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Adolescents and Young Adults With Sickle Cell Disease: Nociplastic Pain and Pain Catastrophizing as Predictors of Pain Interference and Opioid Consumption.

Adolescents and Young Adults With Sickle Cell Disease: Nociplastic Pain and Pain Catastrophizing as Predictors of Pain Interference and Opioid Consumption.

Authors :
Kuisell C
Ploutz-Snyder R
Williams DA
Voepel-Lewis T
Hutchinson RJ
Dudding KM
Bridges C
Lavoie Smith EM
Source :
The Clinical journal of pain [Clin J Pain] 2023 Jul 01; Vol. 39 (7), pp. 326-333. Date of Electronic Publication: 2023 Jul 01.
Publication Year :
2023

Abstract

Objectives: Some patients with sickle cell disease (SCD) have features of nociplastic pain. While research suggests that many patients with nociplastic pain consume more opioids due to opioid nonresponsiveness, little is known about the impact of nociplastic pain and pain catastrophizing on opioid consumption and pain interference among adolescents and young adults (AYA) with SCD. The purpose of this study was to (1) characterize nociplastic pain and pain catastrophizing among AYA with SCD, and (2) determine whether these characterizations are associated with subsequent opioid consumption and pain interference 1 month after characterization.<br />Methods: Participants completed surveys characterizing nociplastic pain and catastrophizing at a routine clinic visit (baseline). Thereafter, participants received weekly text messages that included pain interference and opioid consumption surveys. Multipredictor 2-part models were used to evaluate the predictive relationships between baseline characterizations and subsequent pain interference, and opioid consumption.<br />Results: Forty-eight AYA aged 14 to 35 completed baseline measures. Twenty-five percent of participants had scores suggestive of nociplastic pain. Greater nociplastic pain features significantly increased the odds of consuming opioids (odds ratio=1.2) and having greater interference from pain (odds ratio=1.46). Regression analyses found that greater baseline nociplastic pain characteristics were significantly associated with opioid consumption (β=0.13) and pain interference (β=0.061); whereas higher pain catastrophizing scores predicted less opioid consumption (β=-0.03) and less pain interference (β=-0.0007).<br />Discussion: In this sample of AYA with SCD, features of nociplastic pain predicted higher subsequent opioid consumption and pain interference. Being aware of nociplastic pain features in patients with SCD may better guide individualized pain management.<br />Competing Interests: Funding for this study was provided by the Hillman Advancing Early Research Opportunities Grant (The Rita & Alex Hillman Foundation, New York, NY), Rackham Graduate Student Research Grant (Rackham Graduate School, University of Michigan, Ann Arbor, MI), and the University of Michigan School of Nursing New Investigator Award (Ann Arbor, MI). C.K. received funding from the National Institute of Nursing Research (T32 NR016914). The authors declare no conflict of interest.<br /> (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)

Details

Language :
English
ISSN :
1536-5409
Volume :
39
Issue :
7
Database :
MEDLINE
Journal :
The Clinical journal of pain
Publication Type :
Academic Journal
Accession number :
37083638
Full Text :
https://doi.org/10.1097/AJP.0000000000001119