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Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS.

Authors :
Cunningham DA
Reid AJ
Hosking C
Deroost K
Tumwine-Downey I
Sanders M
Langhorne J
Source :
BMC research notes [BMC Res Notes] 2023 Apr 19; Vol. 16 (1), pp. 56. Date of Electronic Publication: 2023 Apr 19.
Publication Year :
2023

Abstract

Objective: To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice.<br />Results: Infected red blood cells containing female and male P. chabaudi gametocytes transcribe a distinct set of genes encoded by the multigene family pir. The overall patterns are similar to what has been observed in the close relative P. berghei, but here we show that gametocyte-associated pir genes are distinct from those involved in chronic blood-stage infection and highlight a male-associated pir gene which should be the focus of future studies.<br /> (© 2023. The Author(s).)

Details

Language :
English
ISSN :
1756-0500
Volume :
16
Issue :
1
Database :
MEDLINE
Journal :
BMC research notes
Publication Type :
Academic Journal
Accession number :
37076932
Full Text :
https://doi.org/10.1186/s13104-023-06322-1