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Paramagnetic NMR restraints for the characterization of protein structural rearrangements.
- Source :
-
Current opinion in structural biology [Curr Opin Struct Biol] 2023 Jun; Vol. 80, pp. 102595. Date of Electronic Publication: 2023 Apr 17. - Publication Year :
- 2023
-
Abstract
- Mobility is a common feature of biomacromolecules, often fundamental for their function. Thus, in many cases, biomacromolecules cannot be described by a single conformation, but rather by a conformational ensemble. NMR paramagnetic data demonstrated quite informative to monitor this conformational variability, especially when used in conjunction with data from different sources. Due to their long-range nature, paramagnetic data can, for instance, i) clearly demonstrate the occurrence of conformational rearrangements, ii) reveal the presence of minor conformational states, sampled only for a short time, iii) indicate the most representative conformations within the conformational ensemble sampled by the molecule, iv) provide an upper limit to the weight of each conformation.<br />Competing Interests: Conflict of interest statement Nothing declared.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-033X
- Volume :
- 80
- Database :
- MEDLINE
- Journal :
- Current opinion in structural biology
- Publication Type :
- Academic Journal
- Accession number :
- 37075534
- Full Text :
- https://doi.org/10.1016/j.sbi.2023.102595