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Photoactivated Hydrogen Sulfide Donor with a Near-Infrared Fluorescence Report System for Accelerated Chronic Wound Healing.
- Source :
-
Analytical chemistry [Anal Chem] 2023 May 02; Vol. 95 (17), pp. 6931-6939. Date of Electronic Publication: 2023 Apr 19. - Publication Year :
- 2023
-
Abstract
- Delayed wound healing is one of the major diabetes complications that occur in 25% of diabetic patients. Specific wound management and combination treatment are required to repair the wound, which still remains a challenge with few effective therapies available currently. In this work, a new H <subscript>2</subscript> S donor PRO-F , which is characterized by the capability to promote wound healing in diabetes, was designed. PRO-F can be activated by light without consuming endogenous substances and the accompanying fluorescent signal makes the real-time tracking of released H <subscript>2</subscript> S possible. PRO-F is able to deliver H <subscript>2</subscript> S in an intracellular environment with moderate release efficiency (50%), which presents cytoprotective effects against excessive reactive oxygen species (ROS) induced damage. Furthermore, the potential of PRO-F to enhance chronic wound healing was validated by employing diabetic models. This work provides new insights into the therapeutic role of H <subscript>2</subscript> S donors in complex wound conditions, which should advance the pathophysiological research associated with H <subscript>2</subscript> S.
Details
- Language :
- English
- ISSN :
- 1520-6882
- Volume :
- 95
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Analytical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 37074795
- Full Text :
- https://doi.org/10.1021/acs.analchem.3c00230