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Chorionicity and neurodevelopmental outcomes at 5½ years among twins born preterm: the EPIPAGE2 cohort study.
- Source :
-
BJOG : an international journal of obstetrics and gynaecology [BJOG] 2023 Aug; Vol. 130 (9), pp. 1047-1058. Date of Electronic Publication: 2023 Apr 17. - Publication Year :
- 2023
-
Abstract
- Objective: To compare the neurodevelopmental outcomes of preterm twins at 5½ years by chorionicity of pregnancy.<br />Design: Prospective nationwide population-based EPIPAGE2 (Etude Epidémiologique sur les Petits Âges Gestationnels) cohort study.<br />Setting: A total of 546 maternity units in France, between March and December 2011.<br />Population: A total of 1126 twins eligible for follow-up at 5½ years.<br />Methods: The association of chorionicity with outcomes was analysed using multivariate regression models.<br />Main Outcome Measures: Survival at 5½ years with or without neurodevelopmental disabilities (comprising cerebral palsy, visual, hearing, cognitive deficiency, behavioural difficulties or developmental coordination disorders) were described and compared by chorionicity.<br />Results: Among the 1126 twins eligible for follow-up at 5½ years, 926 (82.2%) could be evaluated: 228 monochorionic (MC) and 698 dichorionic (DC). Based on chronicity and gestational age of birth, we found no significant differences for severe neonatal morbidity. The rates of moderate/severe neurobehavioral disabilities were similar in infants from DC pregnancies versus infants from MC pregnancies (OR 1.22, 95% CI 0.65-2.28). By gestational age and without twin-twin transfusion syndrome (TTTS), no difference according to chorionicity was found for all neurodevelopmental outcome measures.<br />Conclusions: The neurodevelopmental outcomes among preterm twins at 5½ years is similar, irrespective of chorionicity.<br /> (© 2023 John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1471-0528
- Volume :
- 130
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- BJOG : an international journal of obstetrics and gynaecology
- Publication Type :
- Academic Journal
- Accession number :
- 37069725
- Full Text :
- https://doi.org/10.1111/1471-0528.17460