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Soluble adhesion molecules and functional outcome after ischemic stroke: A Mendelian randomization study.
- Source :
-
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2023 Jun; Vol. 32 (6), pp. 107136. Date of Electronic Publication: 2023 Apr 15. - Publication Year :
- 2023
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Abstract
- Objectives: We employed Mendelian randomization to determine whether genetically predicted circulating levels of endothelial-derived adhesion molecules (soluble intercellular adhesion molecule-1 [sICAM-1]), soluble vascular-leukocyte adhesion molecule-1 [sVCAM-1], and soluble-endothelial-leukocyte adhesion molecule [sE-selectin]) were associated with functional outcome after ischemic stroke.<br />Methods: Independent genetic variants robustly associated with soluble adhesion molecules, located at or close to the coding gene (cis), were used as genetic instruments. The functional outcome was evaluated using the 3-month modified Rankin Scale (mRS) score after ischemic stroke. A poor functional outcome was defined as mRS ≥ 3 at 3 months. We extracted summary data for functional outcome after ischemic stroke from the Genetics of Ischaemic Stroke Functional Outcome network (n = 6,021).<br />Results: Genetically elevated sICAM-1 (OR 1.28, 95% CI 1.05-1.56) and sE-selectin (OR 2.69, 95% CI 1.23-5.86) levels were related with poor post-stroke outcome. However, we found no evidence that genetically elevated sVCAM-1 were associated with post-stroke outcome (OR 1.36, 95% CI 0.39-4.66).<br />Conclusions: We found that genetically elevated higher sICAM-1 and sE-selectin levels are associated with poor post-stroke outcome. Further studies are warranted to evaluate the potential of ICAM-1 and E-selectin to be drug targets for post-stroke recovery.<br />Competing Interests: Declaration of Competing Interest Dipender Gill is employed part-time by Novo Nordisk. The remaining authors have no competing interests to declare.<br /> (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Vascular Cell Adhesion Molecule-1 genetics
Mendelian Randomization Analysis
Cell Adhesion Molecules genetics
Intercellular Adhesion Molecule-1 genetics
Selectins
Brain Ischemia diagnosis
Brain Ischemia genetics
Brain Ischemia therapy
Ischemic Stroke diagnosis
Ischemic Stroke genetics
Ischemic Stroke therapy
Stroke diagnosis
Stroke genetics
Stroke therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8511
- Volume :
- 32
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- Publication Type :
- Academic Journal
- Accession number :
- 37068323
- Full Text :
- https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107136