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Genetic disorders of neurotransmitter release machinery.
- Source :
-
Frontiers in synaptic neuroscience [Front Synaptic Neurosci] 2023 Mar 31; Vol. 15, pp. 1148957. Date of Electronic Publication: 2023 Mar 31 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- Synaptic neurotransmitter release is an evolutionarily conserved process that mediates rapid information transfer between neurons as well as several peripheral tissues. Release of neurotransmitters are ensured by successive events such as synaptic vesicle docking and priming that prepare synaptic vesicles for rapid fusion. These events are orchestrated by interaction of different presynaptic proteins and are regulated by presynaptic calcium. Recent studies have identified various mutations in different components of neurotransmitter release machinery resulting in aberrant neurotransmitter release, which underlie a wide spectrum of psychiatric and neurological symptoms. Here, we review how these genetic alterations in different components of the core neurotransmitter release machinery affect the information transfer between neurons and how aberrant synaptic release affects nervous system function.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Uzay and Kavalali.)
Details
- Language :
- English
- ISSN :
- 1663-3563
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Frontiers in synaptic neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 37066095
- Full Text :
- https://doi.org/10.3389/fnsyn.2023.1148957