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Unbalanced 1;7 translocation and therapy-induced hematologic disorders: a possible relationship.
- Source :
-
American journal of hematology [Am J Hematol] 1986 Jan; Vol. 21 (1), pp. 39-47. - Publication Year :
- 1986
-
Abstract
- An identical chromosome abnormality, which appears to be derived from a 1;7 translocation [+der(1),t(1;7)(p11;p11)], was observed in the bone marrow of 12 patients with various hematologic disorders at the Mayo Clinic from 1980 to 1984. At the time of cytogenetic evaluation, nine of the patients had either a myeloproliferative disorder or a myelodysplastic syndrome, one had an acute leukemia, and two had treated multiple myeloma with no morphologic evidence of evolving myeloproliferative disease. Of the 11 patients for whom information about previous therapy was available, seven had a history of exposure to chemotherapy for a previous malignant disorder; we were unable to establish whether the remaining patient had had prior treatment. This study suggests a possible relationship between +der(1),t(1;7)(p11;p11) and some treatment-induced hematologic disorders. Such chromosome abnormalities may be the result of a reciprocal chromatid translocation and adjacent I segregation of a quadriradial configuration in metaphase.
- Subjects :
- Adult
Aged
Anemia, Refractory, with Excess of Blasts genetics
Anemia, Refractory, with Excess of Blasts therapy
Antineoplastic Agents adverse effects
Bone Marrow ultrastructure
Female
Hematologic Diseases therapy
Humans
Karyotyping
Leukemia genetics
Leukemia therapy
Male
Middle Aged
Multiple Myeloma genetics
Multiple Myeloma therapy
Myelodysplastic Syndromes genetics
Myelodysplastic Syndromes therapy
Chromosomes, Human, 1-3
Chromosomes, Human, 6-12 and X
Hematologic Diseases genetics
Translocation, Genetic drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0361-8609
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- American journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 3706288
- Full Text :
- https://doi.org/10.1002/ajh.2830210106