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Automated tumor segmentation and brain tissue extraction from multiparametric MRI of pediatric brain tumors: A multi-institutional study.

Authors :
Fathi Kazerooni A
Arif S
Madhogarhia R
Khalili N
Haldar D
Bagheri S
Familiar AM
Anderson H
Haldar S
Tu W
Chul Kim M
Viswanathan K
Muller S
Prados M
Kline C
Vidal L
Aboian M
Storm PB
Resnick AC
Ware JB
Vossough A
Davatzikos C
Nabavizadeh A
Source :
Neuro-oncology advances [Neurooncol Adv] 2023 Mar 16; Vol. 5 (1), pp. vdad027. Date of Electronic Publication: 2023 Mar 16 (Print Publication: 2023).
Publication Year :
2023

Abstract

Background: Brain tumors are the most common solid tumors and the leading cause of cancer-related death among all childhood cancers. Tumor segmentation is essential in surgical and treatment planning, and response assessment and monitoring. However, manual segmentation is time-consuming and has high interoperator variability. We present a multi-institutional deep learning-based method for automated brain extraction and segmentation of pediatric brain tumors based on multi-parametric MRI scans.<br />Methods: Multi-parametric scans (T1w, T1w-CE, T2, and T2-FLAIR) of 244 pediatric patients ( n = 215 internal and n = 29 external cohorts) with de novo brain tumors, including a variety of tumor subtypes, were preprocessed and manually segmented to identify the brain tissue and tumor subregions into four tumor subregions, i.e., enhancing tumor (ET), non-enhancing tumor (NET), cystic components (CC), and peritumoral edema (ED). The internal cohort was split into training ( n = 151), validation ( n = 43), and withheld internal test ( n = 21) subsets. DeepMedic, a three-dimensional convolutional neural network, was trained and the model parameters were tuned. Finally, the network was evaluated on the withheld internal and external test cohorts.<br />Results: Dice similarity score (median ± SD) was 0.91 ± 0.10/0.88 ± 0.16 for the whole tumor, 0.73 ± 0.27/0.84 ± 0.29 for ET, 0.79 ± 19/0.74 ± 0.27 for union of all non-enhancing components (i.e., NET, CC, ED), and 0.98 ± 0.02 for brain tissue in both internal/external test sets.<br />Conclusions: Our proposed automated brain extraction and tumor subregion segmentation models demonstrated accurate performance on segmentation of the brain tissue and whole tumor regions in pediatric brain tumors and can facilitate detection of abnormal regions for further clinical measurements.<br />Competing Interests: None to declare.<br /> (© The Author(s) 2023. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.)

Details

Language :
English
ISSN :
2632-2498
Volume :
5
Issue :
1
Database :
MEDLINE
Journal :
Neuro-oncology advances
Publication Type :
Academic Journal
Accession number :
37051331
Full Text :
https://doi.org/10.1093/noajnl/vdad027