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Towards a Synthesis of the Non-Genetic and Genetic Views of Cancer in Understanding Pancreatic Ductal Adenocarcinoma Initiation and Prevention.
- Source :
-
Cancers [Cancers (Basel)] 2023 Apr 05; Vol. 15 (7). Date of Electronic Publication: 2023 Apr 05. - Publication Year :
- 2023
-
Abstract
- While much of the research in oncogenesis and cancer therapy has focused on mutations in key cancer driver genes, more recent work suggests a complementary non-genetic paradigm. This paradigm focuses on how transcriptional and phenotypic heterogeneity, even in clonally derived cells, can create sub-populations associated with oncogenesis, metastasis, and therapy resistance. We discuss this complementary paradigm in the context of pancreatic ductal adenocarcinoma. A better understanding of cellular transcriptional heterogeneity and its association with oncogenesis can lead to more effective therapies that prevent tumor initiation and slow progression.
Details
- Language :
- English
- ISSN :
- 2072-6694
- Volume :
- 15
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Cancers
- Publication Type :
- Academic Journal
- Accession number :
- 37046820
- Full Text :
- https://doi.org/10.3390/cancers15072159