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Laryngeal tuberculosis in patients treated with adalimumab: a casual or causal connection?
Laryngeal tuberculosis in patients treated with adalimumab: a casual or causal connection?
- Source :
-
BMJ case reports [BMJ Case Rep] 2023 Apr 11; Vol. 16 (4). Date of Electronic Publication: 2023 Apr 11. - Publication Year :
- 2023
-
Abstract
- This article presents two consecutive cases of laryngeal tuberculosis in patients treated with a specific anti-tumour necrosis factor-alpha (adalimumab), with a focus on their diagnostic process and therapeutic management. Both patients presented with aspecific chronic laryngeal symptoms that had been worsening for a few months in one case and for almost 1 year in the other one. They were both studied with fibreoptic laryngoscopy and contrast-enhanced CT and MRI scans. In both cases, the laryngeal biopsy proved negative to Ziehl-Neelsen test, while positive to Koch's bacillus sensitive to rifampicin at PCR test. Both patients completely responded to standard antitubercular antibiotic therapy with rifampicin, isoniazid, pyrazinamide and etambutol protocol.In the differential diagnosis of such patients, laryngeal tuberculosis should be considered due to the reasonable linkage between the immunosuppressant therapy with adalimumab and the tuberculosis infection/reactivation.<br />Competing Interests: Competing interests: None declared.<br /> (© BMJ Publishing Group Limited 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
Details
- Language :
- English
- ISSN :
- 1757-790X
- Volume :
- 16
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- BMJ case reports
- Publication Type :
- Academic Journal
- Accession number :
- 37041038
- Full Text :
- https://doi.org/10.1136/bcr-2023-254742