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Hyponastic Leaves 1 Interacts with RNA Pol II to Ensure Proper Transcription of MicroRNA Genes.
- Source :
-
Plant & cell physiology [Plant Cell Physiol] 2023 Jun 15; Vol. 64 (6), pp. 571-582. - Publication Year :
- 2023
-
Abstract
- Hyponastic Leaves 1 (HYL1) [also known as Double-stranded RNA-Binding protein 1 (DRB1)] is a double-stranded RNA-binding protein involved in microRNA (miRNA) processing in plants. It is a core component of the Microprocessor complex and enhances the efficiency and precision of miRNA processing by the Dicer-Like 1 protein. In this work, we report a novel function of the HYL1 protein in the transcription of miRNA (MIR) genes. HYL1 colocalizes with RNA polymerase II and affects its distribution along MIR genes. Moreover, proteomic experiments revealed that the HYL1 protein interacts with many transcription factors. Finally, we show that the action of HYL1 is not limited to MIR genes and impacts the expression of many other genes, a majority of which are involved in plastid organization. These discoveries indicate HYL1 as an additional player in gene regulation at the transcriptional level, independent of its role in miRNA biogenesis.<br /> (© The Author(s) 2023. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists.)
- Subjects :
- RNA Polymerase II genetics
RNA Polymerase II metabolism
Proteomics
RNA-Binding Proteins genetics
RNA-Binding Proteins metabolism
Plant Leaves genetics
Plant Leaves metabolism
Gene Expression Regulation, Plant
Arabidopsis Proteins genetics
Arabidopsis Proteins metabolism
Arabidopsis genetics
Arabidopsis metabolism
MicroRNAs genetics
MicroRNAs metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1471-9053
- Volume :
- 64
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Plant & cell physiology
- Publication Type :
- Academic Journal
- Accession number :
- 37040378
- Full Text :
- https://doi.org/10.1093/pcp/pcad032