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Residual pulmonary infiltrates, symptoms and diffusion impairment at 1-year after severe COVID-19 infection have different associated factors.
- Source :
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Journal of internal medicine [J Intern Med] 2023 Jul; Vol. 294 (1), pp. 69-82. Date of Electronic Publication: 2023 Apr 17. - Publication Year :
- 2023
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Abstract
- Introduction: After severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia, patients may show lung sequelae on radiology and functional impairment at the 1-year follow-up. We aimed to describe the persistence of symptoms, radiological alterations, or reduced diffusing capacity of the lung for carbon monoxide (D <subscript>LCO</subscript> ) at 1-year follow-up in patients from the Spanish Registry RECOVID.<br />Methods: RECOVID collected symptom and radiological and functional lung tests data on hospitalized patients with coronavirus disease 2019 during the acute phase and at the 6- and 12-month follow-up visits.<br />Results: Of the 2500 enrolled survivors (90% admitted to the ward), 1874 had follow-up visits for up to a year. Of these, 42% continued to present with symptoms, 27% had radiological sequelae and 31% had reduced D <subscript>LCO</subscript> . Independently associated factors included female sex, asthma and the requirement for invasive or non-invasive mechanical ventilation. Complete radiological resolution was 72.2% at 12 months; associated factors with incomplete recovery were age, male sex, oxygen or respiratory support, corticosteroids and an initial SpO <subscript>2</subscript> /FiO <subscript>2</subscript> <450 or CURB-65 ≥2. Reduced D <subscript>LCO</subscript> was observed in 31% of patients at 12 months; associated factors were older age, female sex, smoking habit, SpO <subscript>2</subscript> /FiO <subscript>2</subscript> <450 and CURB-65 ≥2 and the requirement of respiratory support.At 12 months, a proportion of the asymptomatic patients showed reduced D <subscript>LCO</subscript> (9.5%), radiological findings (25%) or both (11%).<br />Conclusions: The factors associated with symptom persistence, incomplete radiological resolution and D <subscript>LCO</subscript> <80% differed according to age, sex, comorbidities and respiratory support. The burden of symptoms, reduced D <subscript>LCO</subscript> and incomplete radiological resolution were considerable in patients with SARS-CoV-2 pneumonia at the 1-year follow-up after hospitalisation.<br /> (© 2023 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of Association for Publication of The Journal of Internal Medicine.)
Details
- Language :
- English
- ISSN :
- 1365-2796
- Volume :
- 294
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 37038609
- Full Text :
- https://doi.org/10.1111/joim.13642