The tanshinones from the plant of Salvia miltiorrhiza.

Authors :: Jiang JS
Gu QC
Feng ZM
Yuan X
Zhang X
Zhang PC
Yang YN
Source :: Phytochemistry [Phytochemistry] 2023 Jun; Vol. 210, pp. 113673. Date of Electronic Publication: 2023 Apr 06.
Publication Year :: 2023
Abstract: Six undescribed tanshinones, (+)-2-Cl-tanshindiol C (1), (-)-2-Cl-tanshindiol C (2), (+)-tanshinoic acid D (3), (-)-tanshinoic acid D (4), (-)-tanshinoic acid E (5), and (+)-tanshinoic acid E (6), were isolated from the rhizome of Salvia miltiorrhiza Bunge. Their structures were elucidated based on the spectroscopic data (UV, IR, HR-ESI-MS, and NMR). The bioactive assays of all these compounds for the antioxidant activities in cardiomyocytes upon hypoxia stimulation were evaluated. The results suggested that compounds 5 and 6 exhibited good antioxidant activities in cardiomyocytes and the cell survival rates were 46.3% and 57.9% (10 <superscript>-5</superscript>  mol/L), respectively.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)