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Cochlear Implants in Deaf Patients with Novel TMPRSS3 Gene Mutation.
- Source :
-
Alternative therapies in health and medicine [Altern Ther Health Med] 2023 Jul; Vol. 29 (5), pp. 102-106. - Publication Year :
- 2023
-
Abstract
- Objective: To investigate the effect of cochlear implants in deaf patients with TMPRSS3 gene pathogenic variations.<br />Methods: Variations of deafness genes were detected in 2 patients with profound hearing loss. Both received unilateral cochlear implantation. Hearing and speech abilities were evaluated and analyzed before and 3 and 6 months after surgery. The analysis included post-surgery evaluation of auditory behavior (Categories of Performance [CAP]) and Speech Intelligibility Rating (SIR).<br />Results: In the 2 patients, 3 pathogenic single nucleotide variations (SNVs) of TMPRSS3 gene and a large deletion in 21q22.3 were detected. The CAP and SIR grades increased with the recovery time.<br />Conclusion: Cochlear implants have a good effect in patients with TMPRSS3 gene mutation deafness. Preoperative gene testing has a certain reference significance for the prognosis in patients with the deafness gene mutation.
Details
- Language :
- English
- ISSN :
- 1078-6791
- Volume :
- 29
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Alternative therapies in health and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 37023310