Intravitreal Fluocinolone Acetonide Implant (ILUVIEN ® ) for the Treatment of Retinal Conditions. A Review of Clinical Studies.

Fluocinolone acetonide (FAc) intravitreal implant (Iluvien ^® ) is a corticosteroid implant indicated for the treatment of diabetic macular oedema (DMO) in patients who have previously received conventional treatment without good response, non-infectious posterior uveitis, and as an off-label treatment of the macular oedema secondary to retinal vein occlusion. FAc is a non-biodegradable 0.19 mg intravitreal implant which is designed to release FAc over 3 years at a rate of approximately 0.2 mcg per day. The aim of this review is to describe the special pharmacological properties of Iluvien and display the outcomes of the most important clinical trials and real-world studies regarding its efficacy and safety for the management of the above retinal disorders.
Competing Interests: Yusuf Mushtaq and Maryam M Mushtaq are co-first authors for this study. Lorenzo Motta and Georgios D Panos are co-correspondence authors for this study. The authors report no conflicts of interest in this work.
(© 2023 Mushtaq et al.)