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Cytotoxic steroids from the stems of Strophanthus divaricatus.

Authors :: Ran HL
Huang SZ
Wang H
Yang L
Gai CJ
Duan RJ
Dai HF
Guan YL
Mei WL
Source :: Phytochemistry [Phytochemistry] 2023 Jun; Vol. 210, pp. 113668. Date of Electronic Publication: 2023 Apr 04.
Publication Year :: 2023
Abstract: Phytochemical investigation on the stems of Strophanthus divaricatus led to the isolation of four undescribed cardiac glycosides and one undescribed C <subscript>21</subscript> pregnane, together with eleven known steroids. Their structures were elucidated by a comprehensive analysis of HRESIMS, 1D and 2D NMR spectra. The absolute configuration of 16 was determined by comparison of the experimental and computed ECD spectra. Compounds 1-13 and 15 displayed potent to significant cytotoxicity against human cancer cell lines K562, SGC-7901, A549 and HeLa with IC <subscript>50</subscript> values of 0.02-16.08, 0.04-23.13, 0.06-22.31 and 0.06-15.13 μM, respectively.<br />Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dai HaoFu reports financial support was provided by Hainan Provincial Natural Science Foundation of China. Mei Wenli reports financial support was provided by Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences. Dai Haofu reports a relationship with Hainan Provincial Natural Science Foundation of China that includes: funding grants. Mei Wenli reports a relationship with Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences that includes: funding grants.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)