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Low-Intensity Pulsed Ultrasound Neuromodulation of a Rodent's Spinal Cord Suppresses Motor Evoked Potentials.

Authors :
Tsehay Y
Zeng Y
Weber-Levine C
Awosika T
Kerensky M
Hersh AM
Ou Z
Jiang K
Bhimreddy M
Bauer SJ
Theodore JN
Quiroz VM
Suk I
Alomari S
Sun J
Tong S
Thakor N
Doloff JC
Theodore N
Manbachi A
Source :
IEEE transactions on bio-medical engineering [IEEE Trans Biomed Eng] 2023 Jul; Vol. 70 (7), pp. 1992-2001. Date of Electronic Publication: 2023 Jun 19.
Publication Year :
2023

Abstract

Objective: Here we investigate the ability of low-intensity ultrasound (LIUS) applied to the spinal cord to modulate the transmission of motor signals.<br />Methods: Male adult Sprague-Dawley rats (n = 10, 250-300 g, 15 weeks old) were used in this study. Anesthesia was initially induced with 2% isoflurane carried by oxygen at 4 L/min via a nose cone. Cranial, upper extremity, and lower extremity electrodes were placed. A thoracic laminectomy was performed to expose the spinal cord at the T11 and T12 vertebral levels. A LIUS transducer was coupled to the exposed spinal cord, and motor evoked potentials (MEPs) were acquired each minute for either 5- or 10-minutes of sonication. Following the sonication period, the ultrasound was turned off and post-sonication MEPs were acquired for an additional 5 minutes.<br />Results: Hindlimb MEP amplitude significantly decreased during sonication in both the 5- (p < 0.001) and 10-min (p = 0.004) cohorts with a corresponding gradual recovery to baseline. Forelimb MEP amplitude did not demonstrate any statistically significant changes during sonication in either the 5- (p = 0.46) or 10-min (p = 0.80) trials.<br />Conclusion: LIUS applied to the spinal cord suppresses MEP signals caudal to the site of sonication, with recovery of MEPs to baseline after sonication.<br />Significance: LIUS can suppress motor signals in the spinal cord and may be useful in treating movement disorders driven by excessive excitation of spinal neurons.

Details

Language :
English
ISSN :
1558-2531
Volume :
70
Issue :
7
Database :
MEDLINE
Journal :
IEEE transactions on bio-medical engineering
Publication Type :
Academic Journal
Accession number :
37018313
Full Text :
https://doi.org/10.1109/TBME.2022.3233345