Pharmacogenetics of cardiovascular drugs.

Authors :: Saleh A
Al-Abcha A
Pereira N
Source :: Current opinion in cardiology [Curr Opin Cardiol] 2023 May 01; Vol. 38 (3), pp. 207-214. Date of Electronic Publication: 2023 Mar 28.
Publication Year :: 2023
Abstract: Purpose of Review: Advances in pharmacogenomics have paved the way for personalized medicine. The purpose of this review is to summarize the background, rationale, and evidence for pharmacogenomics in cardiovascular medicine.<br />Recent Findings: Randomized clinical trials have supported the role of a genotype-guided approach for antiplatelet therapy in patients with coronary artery disease undergoing percutaneous coronary interventions. Additionally, there is increasing evidence supporting the association of certain genetic variants and risk of statin associated muscle symptoms. Furthermore, germline genetic variation is being used as a biomarker to target patients with specific therapy.<br />Summary: Pharmacogenomics has the potential to improve patient care by providing the right drug to the right patient and could guide the identification of novel drug therapies for cardiovascular disease.<br /> (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)