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In vivo tests of a novel wound dressing based on agar aerogel.

Authors :: Athamneh T
Hajnal A
Al-Najjar MAA
Alshweiat A
Obaidat R
Awad AA
Al-Alwany R
Keitel J
Wu D
Kieserling H
Rohn S
Keil C
Gurikov P
Source :: International journal of biological macromolecules [Int J Biol Macromol] 2023 Jun 01; Vol. 239, pp. 124238. Date of Electronic Publication: 2023 Mar 31.
Publication Year :: 2023
Abstract: Aerogels, especially bio-based ones, present a promising option for wound dressing; specifically, because of their low toxicity, high stability, bio-compatibility, and good biological performance. In this study, agar aerogel was prepared and evaluated as novel wound dressing material in an in vivo rat study. Agar hydrogel was prepared by thermal gelation, after that the water inside the gel was exchanged with ethanol, and finally the alcogel was dried by supercritical CO <subscript>2</subscript> . The textural and rheological properties of the prepared aerogel were characterized, showing that the prepared agar aerogels possess high porosity (97-98 %), high surface area (250-330 m <superscript>2</superscript> g <superscript>-1</superscript> ) as well as good mechanical properties and easiness of removal from the wound site. The results of the in vivo experiments macroscopically demonstrate the tissue compatibility of the aerogels in dorsal interscapular injured rat tissue and a shorter wound healing time comparable to that of gauze-treated animals. The histological analysis underpins the reorganisation and healing of the tissue for the injured skin of rats treated with agar aerogel wound dressing within the studied time frame.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023. Published by Elsevier B.V.)