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Clinical presentation and recurrence of pituitary neuroendocrine tumors: results from a single referral center in Colombia.
- Source :
-
Journal of endocrinological investigation [J Endocrinol Invest] 2023 Nov; Vol. 46 (11), pp. 2275-2286. Date of Electronic Publication: 2023 Mar 31. - Publication Year :
- 2023
-
Abstract
- Introduction: Pituitary neuroendocrine tumors (PitNETs) represent 15-18.2% of all intracranial tumors. Their clinical presentation can range from chronic headache, visual defects, hypopituitarism to hormone excess syndromes. PitNETS are commonly classified as functioning neuroendocrine tumors (F-PitNETs) and non-functioning neuroendocrine tumors (NF-PitNETs). At the moment, new classification has emerged based on cell lineages. Almost 50% of all patients with PitNETs require surgical intervention, and about 25% of these have residual and persistent disease that may require additional management.<br />Subjects and Methods: A retrospective cohort of medical records of patients with PitNETs, aiming to describe the incidence of recurrence of patients who received surgical treatment over a 12 month follow up period at San Jose Hospital (SJH) in Bogotá, Colombia, over an observation period of 10 years. Furthermore, clinical presentation, biochemical characteristics and immunohistochemistry, postoperative complications are detailed.<br />Results: Eight hundred and eighty-seven patients with pituitary tumors were included in the cohort; 83% (737/887) had a diagnosis of PitNET. Of these, 18.9% (140) received surgical management. The majority 58% (98/140) had nonfunctional-PitNETs (NF-PitNETs), followed by growth-hormone-secreting pituitary adenoma (22.1%; 33/140), adrenocorticotropic- hormone-secreting pituitary adenoma (9.3%; 13/140), and prolactinomas (9.3%; 13/140). A recurrence was found in 45.71% (64/140), subclassified as biochemical in 15.71% (22/140), controlled with medications in 20% (28/140), and remission occurred in 18.57% (26/140).<br />Conclusion: Clinical presentation and incidence of recurrence in patients with PitNETs in a referral center in Colombia are similar to other surgical cohorts with low cure rates and high recurrence.<br /> (© 2023. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE).)
- Subjects :
- Humans
Colombia epidemiology
Retrospective Studies
Hormones
Pituitary Neoplasms diagnosis
Pituitary Neoplasms epidemiology
Pituitary Neoplasms therapy
Neuroendocrine Tumors diagnosis
Neuroendocrine Tumors epidemiology
Neuroendocrine Tumors surgery
ACTH-Secreting Pituitary Adenoma surgery
Adenoma diagnosis
Adenoma epidemiology
Adenoma therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1720-8386
- Volume :
- 46
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Journal of endocrinological investigation
- Publication Type :
- Academic Journal
- Accession number :
- 37002436
- Full Text :
- https://doi.org/10.1007/s40618-023-02080-w