The impact of non-coding RNAs in the pathobiology of eye disorders.

Authors :: Moallemi Rad L
Sadoughi MM
Nicknam A
Colagar AH
Hussen BM
Taheri M
Ghafouri-Fard S
Source :: International journal of biological macromolecules [Int J Biol Macromol] 2023 Jun 01; Vol. 239, pp. 124245. Date of Electronic Publication: 2023 Mar 29.
Publication Year :: 2023
Abstract: Eye disorders are common disorders with significant effects on personal, economic, and social aspects of life. These disorders have a genetic background and are associated with dysregulation of non-coding RNAs. Three classes of these transcripts, namely long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs) have established roles in the regulation of gene expression and pathoetiology of ocular disorders. H19, MEG3, BANCR, UCA1, HOTAIR, ANRIL, XIST and MIAT are among important lncRNAs in ocular disorders. CircRNAs from ZBTB44, HIPK3, circ-PSEN1, COL1A2, ZNF532 and FAM158A loci have also been found to affect pathoetiology of ocular disorders. Both lncRNAs and circRNAs can serve as molecular sponges for miRNAs. In this review, we searched PubMed and Google Scholar databases to find the research articles summarizing the impact of non-coding RNAs in ocular disorders. The results of these studies would help in identification of suitable targets for treatment of ocular disorders.<br />Competing Interests: Declaration of competing interest The authors declare they have no conflict of interest.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)