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miR-4432 Targets FGFBP1 in Human Endothelial Cells.

Authors :
Avvisato R
Mone P
Jankauskas SS
Varzideh F
Kansakar U
Gambardella J
De Luca A
Matarese A
Santulli G
Source :
Biology [Biology (Basel)] 2023 Mar 16; Vol. 12 (3). Date of Electronic Publication: 2023 Mar 16.
Publication Year :
2023

Abstract

MicroRNAs (miRs) are small non-coding RNAs that modulate the expression of several target genes. Fibroblast growth factor binding protein 1 (FGFBP1) has been associated with endothelial dysfunction at the level of the blood-brain barrier (BBB). However, the underlying mechanisms are mostly unknown and there are no studies investigating the relationship between miRs and FGFBP1. Thus, the overarching aim of the present study was to identify and validate which miR can specifically target FGFBP1 in human brain microvascular endothelial cells, which represent the best in vitro model of the BBB. We were able to identify and validate miR-4432 as a fundamental modulator of FGFBP1 and we demonstrated that miR-4432 significantly reduces mitochondrial oxidative stress, a well-established pathophysiological hallmark of hypertension.

Details

Language :
English
ISSN :
2079-7737
Volume :
12
Issue :
3
Database :
MEDLINE
Journal :
Biology
Publication Type :
Academic Journal
Accession number :
36979151
Full Text :
https://doi.org/10.3390/biology12030459