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Safe-Shields: Basal and Anti-UV Protection of Human Keratinocytes by Redox-Active Cerium Oxide Nanoparticles Prevents UVB-Induced Mutagenesis.
- Source :
-
Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2023 Mar 20; Vol. 12 (3). Date of Electronic Publication: 2023 Mar 20. - Publication Year :
- 2023
-
Abstract
- Cerium oxide nanoparticles (nanoceria), biocompatible multifunctional nanozymes exerting unique biomimetic activities, mimic superoxide-dismutase and catalase through a self-regenerating, energy-free redox cycle driven by Ce <superscript>3+/4+</superscript> valence switch. Additional redox-independent UV-filter properties render nanoceria ideal multitask solar screens, shielding from UV exposure, simultaneously protecting tissues from UV-oxidative damage. Here, we report that nanoceria favour basal proliferation of primary normal keratinocytes, and protects them from UVB-induced DNA damage, mutagenesis, and apoptosis, minimizing cell loss and accelerating recovery with flawless cells. Similar cell-protective effects were found on irradiated noncancerous, but immortalized, p53-null HaCaT keratinocytes, with the notable exception that here, nanoceria do not accelerate basal HaCaT proliferation. Notably, nanoceria protect HaCaT from oxidative stress induced by irradiated titanium dioxide nanoparticles, a major active principle of commercial UV-shielding lotions, thus neutralizing their most critical side effects. The intriguing combination of nanoceria multiple beneficial properties opens the way for smart and safer containment measures of UV-induced skin damage and carcinogenesis.
Details
- Language :
- English
- ISSN :
- 2076-3921
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Antioxidants (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 36979005
- Full Text :
- https://doi.org/10.3390/antiox12030757