Role of ferroptosis in pregnancy related diseases and its therapeutic potential.

Authors :: Xu J
Zhou F
Wang X
Mo C
Source :: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Mar 08; Vol. 11, pp. 1083838. Date of Electronic Publication: 2023 Mar 08 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Ferroptosis is a form of regulated cell death characterized by iron overload, overwhelming lipid peroxidation, and disruption of antioxidant systems. Emerging evidence suggests that ferroptosis is associated with pregnancy related diseases, such as spontaneous abortion, pre-eclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, and spontaneous preterm birth. According to these findings, inhibiting ferroptosis might be a potential option to treat pregnancy related diseases. This review summarizes the mechanisms and advances of ferroptosis, the pathogenic role of ferroptosis in pregnancy related diseases and the potential medicines for its treatment.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Xu, Zhou, Wang and Mo.)

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