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Evaluation of an in-house IgM/IgG lateral flow assay for serodiagnosis of human brucellosis.
- Source :
-
Indian journal of medical microbiology [Indian J Med Microbiol] 2023 Mar-Apr; Vol. 42, pp. 55-58. Date of Electronic Publication: 2023 Feb 03. - Publication Year :
- 2023
-
Abstract
- This study aimed to evaluate the diagnostic efficacy of an in-house lateral flow assay (LFA) for the detection of IgM/IgG anti-Brucella antibodies for rapid serodiagnosis of human brucellosis. Three groups of sera samples including 476 from high-risk individuals, 27 from culture-confirmed patients, and 43 from healthy blood donors were used for evaluation of LFA. In comparison with iELISA, the sensitivity, specificity, and accuracy of LFA were >95%, >99%, and 99% respectively. Considering the very good agreement, accuracy, simplicity, and rapidity, LFAs might be useful as a point of care test for the diagnosis of human brucellosis in resource-limited laboratories.<br />Competing Interests: Declaration of competing interest We declare that the authors have no conflicts of interest.<br /> (Copyright © 2023 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1998-3646
- Volume :
- 42
- Database :
- MEDLINE
- Journal :
- Indian journal of medical microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 36967218
- Full Text :
- https://doi.org/10.1016/j.ijmmb.2023.01.006