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Predictors of Myocardial Ischemia in Patients with Kawasaki Disease: Insights from Patient-Specific Simulations of Coronary Hemodynamics.
- Source :
-
Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2023 Oct; Vol. 16 (5), pp. 1099-1109. Date of Electronic Publication: 2023 Mar 20. - Publication Year :
- 2023
-
Abstract
- Current treatments for patients with coronary aneurysms caused by Kawasaki disease (KD) are based primarily on aneurysm size. This ignores hemodynamic factors influencing myocardial ischemic risk. We performed patient-specific computational hemodynamics simulations for 15 KD patients, with parameters tuned to patients' arterial pressure and cardiac function. Ischemic risk was evaluated in 153 coronary arteries from simulated fractional flow reserve (FFR), wall shear stress, and residence time. FFR correlated weakly with aneurysm [Formula: see text]-scores (correlation coefficient, [Formula: see text]) but correlated better with the ratio of maximum-to-minimum aneurysmal lumen diameter ([Formula: see text]). FFR dropped more rapidly distal to aneurysms, and this correlated more with the lumen diameter ratio ([Formula: see text]) than [Formula: see text]-score ([Formula: see text]). Wall shear stress correlated better with the diameter ratio ([Formula: see text]), while residence time correlated more with [Formula: see text]-score ([Formula: see text]). Overall, the maximum-to-minimum diameter ratio predicted ischemic risk better than [Formula: see text]-score. Although FFR immediately distal to aneurysms was nonsignificant, its rapid rate of decrease suggests elevated risk.<br /> (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Humans
Hemodynamics
Coronary Vessels diagnostic imaging
Coronary Angiography
Fractional Flow Reserve, Myocardial
Mucocutaneous Lymph Node Syndrome complications
Mucocutaneous Lymph Node Syndrome diagnosis
Coronary Artery Disease etiology
Coronary Artery Disease complications
Myocardial Ischemia etiology
Myocardial Ischemia complications
Coronary Aneurysm diagnostic imaging
Coronary Aneurysm etiology
Coronary Stenosis
Subjects
Details
- Language :
- English
- ISSN :
- 1937-5395
- Volume :
- 16
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular translational research
- Publication Type :
- Academic Journal
- Accession number :
- 36939959
- Full Text :
- https://doi.org/10.1007/s12265-023-10374-w