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PReS-endorsed international childhood lupus T2T task force definition of childhood lupus low disease activity state (cLLDAS).
- Source :
-
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2023 May; Vol. 250, pp. 109296. Date of Electronic Publication: 2023 Mar 17. - Publication Year :
- 2023
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Abstract
- Objective: To achieve a consensus-based definition of Low Disease Activity (LDA) for use in cSLE trials.<br />Methods: The International cSLE T2T Task Force, comprising of paediatric rheumatologists/nephrologists, and adult rheumatologists undertook a series of Delphi surveys/consensus meetings to discuss, refine, and vote upon cSLE LDA criteria.<br />Results: The Task Force agreed that LDA should be based upon the adult-SLE Lupus Low Disease Activity State definition (LLDAS), with modifications to make it applicable to cSLE (cLLDAS). They agreed upon five cLLDAS criteria: (1) SLE Disease Activity Index (SLEDAI)-2 K ≤4, with no activity in major organ systems; (2) no new features of lupus disease activity compared with the last assessment; (3) Physician Global Assessment score of ≤1 (0-3 scale); (4) prednisolone dose of ≤0.15 mg/kg/day, 7.5 mg/day/maximum; while on (5) stable antimalarials, immunosuppressives, and biologics.<br />Conclusions: A cSLE-appropriate definition of cLLDAS has been generated, maintaining alignment with the adult-SLE definition to promote life-course research.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests in relation to this manuscript.<br /> (Copyright © 2023. Published by Elsevier Inc.)
Details
- Language :
- English
- ISSN :
- 1521-7035
- Volume :
- 250
- Database :
- MEDLINE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 36934849
- Full Text :
- https://doi.org/10.1016/j.clim.2023.109296