Cholesteric liquid crystal biosensor platform with image analysis for rapid detection of COVID-19.

Authors :: Lin PY
Chung YW
Chuang EY
Wang YC
Lai MC
Hsu YC
Lin CC
Hsiao YC
Source :: Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2023 Feb 28; Vol. 11, pp. 1148446. Date of Electronic Publication: 2023 Feb 28 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Rapid and low-cost diagnosis of coronavirus disease 2019 (COVID-19) is essential to identify infected subjects, particularly asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to the RT-PCR technique, offer only limited help due to high false positives. We propose to exploit our cholesteric liquid crystal biosensor platform for one-step, wash-free, rapid detection of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus directly with minimal sample pre-processing. As mentioned above, cholesteric liquid crystals are an effective and innovative approach to healthcare as a rapid test for the diagnosis of COVID-19 and other diseases.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Lin, Chung, Chuang, Wang, Lai, Hsu, Lin and Hsiao.)

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