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C-Terminal modification of polytheonamide B uncouples its dual functions in MCF-7 cancer cells.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Mar 28; Vol. 59 (26), pp. 3914-3917. Date of Electronic Publication: 2023 Mar 28. - Publication Year :
- 2023
-
Abstract
- Polytheonamide B (1) is an exceptionally large peptide that forms a transmembrane ion channel. The potent cytotoxicity of 1 against MCF-7 cancer cells originates from its two ion transport functions. Compound 1 depolarizes the plasma membrane and neutralizes acidic lysosomes. Here, we describe how we uncoupled these functions by designing and synthesizing new analogues of 1.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 59
- Issue :
- 26
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 36919651
- Full Text :
- https://doi.org/10.1039/d2cc05915k