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Healthcare worker access to molnupiravir: A case series.

Authors :
O'Keeffe JC
Constable M
Chiang J
Somerville M
Yerramilli A
Nolan R
Weeks G
O'Brien DP
Source :
PloS one [PLoS One] 2023 Mar 14; Vol. 18 (3), pp. e0282695. Date of Electronic Publication: 2023 Mar 14 (Print Publication: 2023).
Publication Year :
2023

Abstract

Molnupiravir, an oral antiviral shown to reduce COVID-19 severity, is available in Australia via the Pharmaceutical Benefits Scheme (PBS) for treatment of mild-moderate COVID-19. For people less than 70 years of age it is only available with risk factors for severe disease, hence the majority of healthcare workers do not qualify. Currently, Australian health services are under considerable strain due to COVID-related staff shortages. Thirty staff members of a tertiary hospital, not eligible under the PBS, were offered molnupiravir within the first five days of COVID-19 illness. Their median age was 43 years, and 73% were female. All completed treatment with rates of adverse events that were low and comparable with clinical trial data. The reported duration of illness ranged from 1-16 days with a median of four days. A negative rapid antigen test on the final day of treatment was reported in 81% of people, and 73% reported being well enough to return to work at the completion of mandatory isolation. Only 22% of people reported transmission in their household after they commenced treatment. The implementation of a policy allowing access to molnupiravir outside of PBS recommendations for healthcare workers with mild-moderate COVID-19 may have important individual benefits to workers health and wellbeing and help alleviate the acute staff shortages experienced currently by the Australian healthcare workforce.<br />Competing Interests: The authors have declared that no competing interests exist.<br /> (Copyright: © 2023 O’Keeffe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Details

Language :
English
ISSN :
1932-6203
Volume :
18
Issue :
3
Database :
MEDLINE
Journal :
PloS one
Publication Type :
Academic Journal
Accession number :
36917596
Full Text :
https://doi.org/10.1371/journal.pone.0282695