Back to Search
Start Over
Performance of the allometric power model in scaling from adult to paediatric antiretroviral dose in children at a Referral Hospital in Windhoek, Namibia.
- Source :
-
African health sciences [Afr Health Sci] 2022 Sep; Vol. 22 (3), pp. 436-441. - Publication Year :
- 2022
-
Abstract
- Background: World Health Organization (WHO) advocates use of weight bands in antiretroviral therapy (ART) guidelines. Allometric scaling could be a more reliable method because it uses a non-linear approach in relating dose to body weight. This study evaluates performance of the allometric ¾ power model in comparison to WHO weight band method in children receiving ART.<br />Methods: Records of children receiving (ABC/3TC) + DTG were reviewed. Paediatric ABC/3TC dose was calculated from the adult dose using the allometric ¾ power model and compared to WHO weight band dose.<br />Results: WHO weight band strategy grouped 50.6% of the children in the 25 kg category and therefore received the adult dose of ABC/3TC (600 mg/300 mg); only 1.1% received this dose with allometric scaling. Mean dose (3.8 tablets) for the WHO weight band dosing method was found to be significantly higher (p<0.0001) than for allometric scaling (1.5 tablets).<br />Conclusions: WHO weight bands may result in the 25 kg weight category receiving a much higher dose leading to ADRs. Using allometric scaling, we recommend a weight band strategy that could improve paediatric ABC/3TC dosing.<br /> (© 2022 Singu BS et al.)
Details
- Language :
- English
- ISSN :
- 1729-0503
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- African health sciences
- Publication Type :
- Academic Journal
- Accession number :
- 36910388
- Full Text :
- https://doi.org/10.4314/ahs.v22i3.47