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A case of acute lymphocytic gastritis related to treatment with pembrolizumab for metastatic urothelial carcinoma.
- Source :
-
IJU case reports [IJU Case Rep] 2022 Dec 20; Vol. 6 (2), pp. 128-132. Date of Electronic Publication: 2022 Dec 20 (Print Publication: 2023). - Publication Year :
- 2022
-
Abstract
- Introduction: Immune checkpoint inhibitors such as programmed cell death/-ligand 1 inhibitor and cytotoxic T-lymphocyte-associated antigen-4 inhibitors have been widely used for various advanced malignancies. The mechanism of action for these inhibitors is the improvement of antitumor immunity via T-cell modulation. On the contrary, immune-related adverse events such as autoimmune colitis might arise in association with T-cell activation. Upper gastrointestinal adverse events related to pembrolizumab have rarely been reported.<br />Case Presentation: A 72-year-old man underwent laparoscopic radical cystectomy for muscle-invasive bladder cancer (pT2N0M0). Multiple lymph node metastases appeared in the paraaortic region. First-line chemotherapy comprising gemcitabine and carboplatin failed to stop disease progression. After the administration of pembrolizumab as second-line treatment, the patient showed symptomatic gastroesophageal reflux disease. Esophagogastroduodenoscopic biopsy of the gastric body showed severe lymphoplasmacytic and neutrophilic infiltration.<br />Conclusion: We present acute gastritis related to pembrolizumab. Early eradication therapy may be able to control immune checkpoint inhibitor-related gastritis.<br />Competing Interests: The authors declare no conflicts of interest.<br /> (© 2022 The Authors. IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of Japanese Urological Association.)
Details
- Language :
- English
- ISSN :
- 2577-171X
- Volume :
- 6
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- IJU case reports
- Publication Type :
- Report
- Accession number :
- 36874988
- Full Text :
- https://doi.org/10.1002/iju5.12568