Breast cancer relapses considering molecular biological characteristics.

Authors :: Smolanka II
Movchan OV
Bagmut IY
Sheremet MI
Kolisnyk IL
Dosenko IV
Lyashcnko AO
Ivankova OM
Loboda AD
Shidlovskyi OV
Source :: Journal of medicine and life [J Med Life] 2023 Jan; Vol. 16 (1), pp. 70-75.
Publication Year :: 2023
Abstract: We aimed to analyze the frequency of breast cancer relapses and their relationship with molecular and biological tumor characteristics. We studied 6,136 breast cancer patients, including 146 with relapses (Group 1) and 455 without relapses (Group 2). We divided the patients based on age, menstrual function, disease stage, histology form and grade, and molecular-biological subtype. The 5-year relapse-free rate for Group 1 was longer for Lum A and TN subtypes (60% and 40%, respectively) but shorter for Lum B and HER-2/neu-amplified subtypes (38% and 31%, respectively). Disease stage, tumor histology, and grade did not significantly affect relapse frequency in these patients. Relapses were more common in premenopausal patients and the Lum B subtype.<br />Competing Interests: The authors declare no conflict of interest.<br /> (©2022 JOURNAL of MEDICINE and LIFE.)