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Mechanisms controlling metabolite concentrations of the Calvin Benson Cycle.
- Source :
-
Seminars in cell & developmental biology [Semin Cell Dev Biol] 2024 Mar 01; Vol. 155 (Pt A), pp. 3-9. Date of Electronic Publication: 2023 Feb 28. - Publication Year :
- 2024
-
Abstract
- Maintaining proper metabolite levels in a complex metabolic network is crucial for maintaining a high flux through the network. In this paper, we discuss major regulatory mechanisms over the Calvin Benson Cycle (CBC) with regard to their roles in conferring homeostasis of metabolite levels in CBC. These include: 1) Redox regulation of enzymes in the CBC on one hand ensures that metabolite levels stay above certain lower bounds under low light while on the other hand increases the flux through the CBC under high light. 2) Metabolite regulations, especially allosteric regulations of major regulatory enzymes, ensure the rapid up-regulation of fluxes to ensure sufficient amount of triose phosphate is available for end product synthesis and concurrently avoid phosphate limitation. 3) A balanced activities of enzymes in the CBC help maintain balanced flux through CBC; some innate product feedback mechanisms, in particular the ADP feedback regulation of GAPDH and F6P feedback regulation of FBPase, exist in CBC to achieve such a balanced enzyme activities and hence flux distribution in the CBC for greater photosynthetic efficiency. Transcriptional regulation and natural variations of enzymes controlling CBC metabolite homeostasis should be further explored to maximize the potential of engineering CBC for greater efficiency.<br />Competing Interests: Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023. Published by Elsevier Ltd.)
- Subjects :
- Photosynthesis physiology
Phosphates
Subjects
Details
- Language :
- English
- ISSN :
- 1096-3634
- Volume :
- 155
- Issue :
- Pt A
- Database :
- MEDLINE
- Journal :
- Seminars in cell & developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 36858897
- Full Text :
- https://doi.org/10.1016/j.semcdb.2023.02.009