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Risk Stratification for Oropharyngeal Squamous Cell Carcinoma Using Texture Analysis on CT - A Step Beyond HPV Status.
- Source :
-
Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes [Can Assoc Radiol J] 2023 Nov; Vol. 74 (4), pp. 657-666. Date of Electronic Publication: 2023 Mar 01. - Publication Year :
- 2023
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Abstract
- Background and Purpose: Human papillomavirus-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasingly prevalent. Despite the overall more favorable outcome, the observed heterogeneous treatment response within this patient group highlights the need for additional means to prognosticate and guide clinical decision-making. Promising prediction models using radiomics from primary OPSCC have been derived. However, no model/s using metastatic lymphadenopathy exist to allow prognostication in those instances when the primary tumor is not seen. The aim of our study was to evaluate whether radiomics using metastatic lymphadenopathy allows for the development of a useful risk assessment model comparable to the primary tumor and whether additional knowledge of the HPV status further improves its prognostic efficacy. Materials and Methods: 80 consecutive patients diagnosed with stage III-IV OPSCC between February 2009 and October 2015, known human papillomavirus status, and pre-treatment CT images were retrospectively identified. Manual segmentation of primary tumor and metastatic lymphadenopathy was performed and the extracted texture features were used to develop multivariate assessment models to prognosticate treatment response. Results: Texture analysis of either the primary or metastatic lymphadenopathy from pre-treatment enhanced CT images can be used to develop models for the stratification of treatment outcomes in OPSCC patients. AUCs range from .78 to .85 for the various OPSCC groups tested, indicating high predictive capability of the models. Conclusions: This preliminary study can form the basis multi-centre trial that may help optimize treatment and improve quality of life in patients with OPSCC in the era of personalized medicine.<br />Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Humans
Squamous Cell Carcinoma of Head and Neck
Retrospective Studies
Quality of Life
Human Papillomavirus Viruses
Prognosis
Tomography, X-Ray Computed
Risk Assessment
Oropharyngeal Neoplasms diagnostic imaging
Oropharyngeal Neoplasms pathology
Oropharyngeal Neoplasms therapy
Carcinoma, Squamous Cell diagnostic imaging
Papillomavirus Infections diagnostic imaging
Papillomavirus Infections pathology
Lymphadenopathy diagnostic imaging
Head and Neck Neoplasms
Subjects
Details
- Language :
- English
- ISSN :
- 1488-2361
- Volume :
- 74
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes
- Publication Type :
- Academic Journal
- Accession number :
- 36856197
- Full Text :
- https://doi.org/10.1177/08465371231157592